Faithful to its innovation strategy, SILAB establishes scientific partnerships with university research teams each year.
Four publications related to these latest scientific advances in the field of skin have just been accepted in impact factor journals:
A research partnership with the University of California San Diego has highlighted an unknown influence of Cutibacterium acnes on the lipid composition of the epidermis. Indeed, this commensal microbial strain induces an increase in lipids essential for the establishment of the barrier function.
Commensal Cutibacterium acnes induce epidermal lipid synthesis important for skin barrier function, Almoughrabie S. et al., Sci adv., 2023 Aug.
Work carried out with the Collège de France and the Institut de génomique fonctionnelle de Lyon made it possible to develop an in vitro skin model from cell sheets. Analysis of gene expression profiles and characterization of the extracellular matrix produced revealed angiogenic properties specific to papillary and reticular fibroblasts.
Papillary and reticular fibroblasts generate distinct microenvironments that differentially impact angiogenesis, Mauroux A. et al., Acta Biomater., 2023 Sep.
In partnership with University of Laval Québec, a cell extraction technique was developed to isolate resident skin cells from the same human donor while preserving immune and endothelial cells. This approach allowed the reconstruction of an autologous, vascularized, and immunocompetent skin model.
An in vitro autologous, vascularized, and immunocompetent Tissue Engineered Skin model obtained by the self-assembled approach, Attiogbe E. et al., Acta Biomater., 2023 Sep.
A research partnership with the University of Reims Champagne-Ardenne has enabled the characterization of the hygroscopic potential of apiogalacturonans. In silico investigation by molecular modeling highlighted a significant hygroscopic potential.
Highlighting the hygroscopic capacities of apiogalacturonans, Verzeaux L. et al., J Mol Graph Model., 2023 Sep.
